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Pediatric Liver & Metabolic Disease

This module provides comprehensive training in pediatric hepatology, covering the systematic evaluation of neonatal cholestasis, biliary atresia, inherited cholestatic and metabolic liver diseases, viral and autoimmune hepatitis, pediatric acute liver failure, portal hypertension, and the principles of pediatric liver transplantation.

Lessons

Hours

CME

119

Questions

Learning Objectives

Develop a systematic diagnostic approach to the infant with direct (conjugated) hyperbilirubinemia, with emphasis on excluding biliary atresia before 45-60 days of life.

Differentiate low-GGT from high-GGT cholestatic syndromes and recognize the clinical patterns of PFIC and Alagille syndrome.

Diagnose and initiate management of inherited metabolic liver diseases including Wilson disease, alpha-1-antitrypsin deficiency, galactosemia, and hereditary tyrosinemia type 1.

Apply King's College criteria and coordinate the initial stabilization of a child with acute liver failure, including timely referral for transplant evaluation.

Manage the complications of pediatric portal hypertension, including variceal bleeding and ascites.

Describe the indications, PELD-based prioritization, and long-term follow-up considerations for pediatric liver transplantation.

Pediatric Liver & Metabolic Disease

Lessons

Hours

CME

119

Questions

Learning Objectives

Develop a systematic diagnostic approach to the infant with direct (conjugated) hyperbilirubinemia, with emphasis on excluding biliary atresia before 45-60 days of life.

Differentiate low-GGT from high-GGT cholestatic syndromes and recognize the clinical patterns of PFIC and Alagille syndrome.

Diagnose and initiate management of inherited metabolic liver diseases including Wilson disease, alpha-1-antitrypsin deficiency, galactosemia, and hereditary tyrosinemia type 1.

Apply King's College criteria and coordinate the initial stabilization of a child with acute liver failure, including timely referral for transplant evaluation.

Manage the complications of pediatric portal hypertension, including variceal bleeding and ascites.

Describe the indications, PELD-based prioritization, and long-term follow-up considerations for pediatric liver transplantation.

Pediatric Liver & Metabolic Disease

Learning Objectives

Approach to Neonatal Cholestasis

Biliary Atresia: Diagnostic Evaluation

Kasai Portoenterostomy: Timing and Technique

Post-Kasai Complications and Long-Term Outcomes

Progressive Familial Intrahepatic Cholestasis (PFIC) Types 1-3

Alagille Syndrome

The GGT-Based Approach to Cholestatic Liver Disease

Viral Hepatitis A-E in Children

Autoimmune Hepatitis in Children

Autoimmune Sclerosing Cholangitis and IBD Overlap

Wilson Disease

Alpha-1-Antitrypsin Deficiency

Galactosemia and Hereditary Tyrosinemia Type 1

Glycogen Storage Disease: Hepatic Involvement

Pediatric Acute Liver Failure: Etiology and King's College Criteria

Portal Hypertension and Variceal Bleeding in Children

Ascites Management in Pediatric Liver Disease

Pediatric Liver Transplantation: Indications, PELD, and Follow-Up

Pediatric Liver & Metabolic Disease

Learning Objectives

Approach to Neonatal Cholestasis

Biliary Atresia: Diagnostic Evaluation

Kasai Portoenterostomy: Timing and Technique

Post-Kasai Complications and Long-Term Outcomes

Progressive Familial Intrahepatic Cholestasis (PFIC) Types 1-3

Alagille Syndrome

The GGT-Based Approach to Cholestatic Liver Disease

Viral Hepatitis A-E in Children

Autoimmune Hepatitis in Children

Autoimmune Sclerosing Cholangitis and IBD Overlap

Wilson Disease

Alpha-1-Antitrypsin Deficiency

Galactosemia and Hereditary Tyrosinemia Type 1

Glycogen Storage Disease: Hepatic Involvement

Pediatric Acute Liver Failure: Etiology and King's College Criteria

Portal Hypertension and Variceal Bleeding in Children

Ascites Management in Pediatric Liver Disease

Pediatric Liver Transplantation: Indications, PELD, and Follow-Up